Covid vs. taxifolin


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A team from the Swiss Faculty of Pharmaceutical Sciences at the University of Basel, led by André Fischer, Manuel Sellner, Santhosh Neranjan, Markus A. Lill, and Martin Smieško, has provided the study development free of charge, which is the most comprehensive screening calculation for SARS to date. Of the 687 million compounds, they began looking for substances that would be able to inhibit the SARS-CoV-2 protease. (Proteases play an important role in many processes such as fertilization, digestion, growth, maturation, aging, and even death of the body. These enzymes regulate numerous physiological processes by controlling activation, synthesis, and degradation of proteins. They also play an important role in the replication and spread of viruses, bacteria and parasites. They are responsible for the effective transmission of the disease caused by these pathogens).

Using computer-aided methods, Basel researchers have tested tens of millions of substances over the past few weeks to determine if they bind to the most important SARS-CoV-2 protease. The research group decided to immediately disclose their results to the public as an open-source in relation to the current crisis. The publication was read more than 3,000 times in the first 48 hours. Scientists hope that other research groups will take their suggestions, test them on the virus, and start further research.

To date, no specific drugs or vaccines are available for the treatment of SARS-CoV-2, despite its close association with the SARS-CoV-1 virus, which caused a similar epidemic in 2003. Therefore, there is an urgent need to develop specific antiviral drugs to overcome SARS-CoV-2.

To find new inhibitors, an electronic library of compounds containing over 687 million compounds was searched for binding to the crystal structure of the main SARS-CoV-2 protease. Screening such a large chemical space for SARS-CoV-2 protease inhibitors has not been undertaken before. After checking the shape, two docking protocols were used, and then pharmacokinetically relevant molecular descriptors were determined to narrow initial hits to confirm the stability of docked binding modes and to fully estimate ligand binding energy. A list of 11 compounds was isolated. Taxifolin was among them. Taxifolin larch, according to the researchers, may also inhibit the main coronavirus protease.

Taxifolin is a flavonoid found in larch. It is remarkable that Taxifolin has 7 hydrogen bonds, which was the largest number of active substances selected by the Swiss University of Basel. The more hydrogen bonds, the wider the coupling. The number of hydrogen bonds is a key factor. More specifically, hydrogen atoms have strongly positively charged partial charges. This type of partial charge is responsible for the fact that a hydrogen atom can connect to an adjacent molecule by attaching to a single pair of electrons (negative charge). In other words, the combination of taxifolin with the main SARS-CoV-2 protease blocks it and thus stops or does not cause the virus to multiply.

Larch taxifolin is a plant substance-free of side effects, showing no toxicity. It has been approved by EFSA (European Food Safety Authority) as a safe measure for humans. It is used in dietary supplements and is intended for daily supplementation. It also has antibacterial and anti-inflammatory effects. In vivo experiments with taxifolin also showed activity against other viruses such as the Coxsackie B4 virus. These viruses mainly cause colds, viral meningitis and myocarditis.

The original version of the study in English is available here:


Diabetes itch and the impact of the dihydroquercetin (taxifolin)


Persons suffering from diabetes often accompanied problems with the skin and its diseases including thrush. The main reason for skin hypersensitivity in the person with diabetes are vascular lesions (diabetic angiopathia), which, in the same way may relate to the larger and smaller vessels. Simply put, we can say that the excess sugar in the blood leads to degenerative changes in capillaries, arterioles, and veins, resulting in impairment of vascular and malnutrition of the skin.

Various forms and stages of onychomycosis feet Source:


Diabetes affects yeast and fungal infection caused by fluctuations in blood sugar levels that facilitate the development of micro-organisms. Dihydroquercetin helps in the treatment of ringworm. In 2009 year, in the published work, its purpose was to investigate the impact of dihydroquercetin on intensity of LPO processes (deregulation of lipid peroxidation of lipids) and degree of endogenous intoxication in patients with diabetes during treatment for fungal nail infection by using the medicine Orungal.

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Radioprotective properties of taxifolin

People who have to deal with cancer often touches on the problem of complications after irradiation.
Under the influence of radiation damage is, first and foremost, blood vessels and connective tissue. After irradiation can also experience additional symptoms that may occur at the same time, these include among others. fatigue, general weakness, reduce the natural resistance of the organism, anorexia, depression, changes in activity in the blood (reduction in the number of white blood cells and platelets), skin reactions, redness, hair loss on the scalp irradiated, only in the case of brain tumors, mucosal reactions in the oral cavity, pharynx, larynx, nasal cavities when irradiated tumors of the head and neck, skin reactions, respiratory and heart (late) in the irradiated organ chest, skin reactions and entero-bullous when irradiated with a range of reactions and belly of the rectum, the vagina, the vulva with pelvic irradiated.

In some cases, especially when irradiated is the thorax may cause damage to the heart muscle, especially when applied to high doses of radiation for cancer of the lungs, lymph nodes in the mediastinum, covering the area between the lungs in close to the heart.

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Taxifolin and diabetic retinopathy

Hiperglycaemia and oxidative stress activate a few bad trails, such as the poliol trail, kinases protein C (PKC), final products of advanced glycation of proteins (AGEs) and heksozoamin that which are responsible for the pathological changes in the blood microcirculation and retinal microcirculation and nerve cells and glial.

Oxidative stress in diabetes is the result of high concentrations of glucose and fatty acids. This plays an important role in the pathogenesis of diabetes and its complications. Its pathogenic activity involves, inter alia, on the inhibition of the synthesis of insulin in pancreatic beta cells and inhibition of signal transmission in target cells with an insulinic. This action contributes to the development of insulin resistance and induce changes in the walls of the blood vessels leading to the complications of diabetes.

Complications include damage to the retina, called as diabetic retinopathy. Diabetic retinopathy is formed as a result of damage to the small blood vessels that nourish the retina, leading to a brain hemorrhage in the eyeball. Increasingly scientists carry out research on the effectiveness of the use of antioxidants, which may have a potential impact on metabolic changes in diabetic retinopathy. In view of the good prognostic antioxidant properties dihydroquercetin (taxifolin) it has been decided to carry out control tests in the field of health support blood vessels in diabetics.

1 / first picture shows the normal vision photo Source: Internet
Eye_disease_simulation,_diabetic_retinopathy Source photo: internet

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Does diabetes lead to damage of the blood vessels?

Complications of diabetes are most commonly associated with damaged blood vessels, atherosclerosis, coronary artery disease, damage to the retina of the eye and kidney disease. The disease can last for years before being detected, which is very dangerous, as even a small increase in blood sugar levels can damage the blood vessels and accelerate atherosclerotic processes. Therefore, diabetes should not be underestimated, even if this is the initial stage of development of this disease, because it contributes to the development of atherosclerosis, and this is the most common cause of death. High blood sugar levels helps the formation of atherosclerotic plaques, gradually tapered diameter of the coronary arteries.

widoczne zmiany miażdżycowe aorty
visible atherosclerotic lesions of the aorta Source photo: internet

A change in the metabolism of the heart cells causes an increased need for nutrients with limited blood supply. This is the cause of myocardial ischemia, which can lead to heart attack, heart failure and sudden death of a heart. The risk of heart attack in hospitalised patients with diabetes is very large. Diabetics must therefore pay particular attention to the control of the General State of health and rapid response in the event of distressing symptoms.

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The quality and purity of the taxifolin by orac

Scientists discovered thousands of antioxidants of wihich 500 is well-understood. Many of them can be obtained only under laboratory conditions, others occur widely in nature, mostly in food. In our home market we have a few dozen as vitamin A (retinol), witamin E (tocopherol), vitamin C, rutin, quercetin, hesperidin, naringenin. Until the interest the topic I knew 3 of them. It just shows how low our consciousness is in dealing with the pathogenesis of diseases and the use of antioxidants. In the English-language medical press appear from time to time reports of newly discovered antioxidants and ongoing research into their application. With tracked literature you can also find out about the origins of antioxidants-how to place of origin determines the purity and power of antioxidants. One way to estimate this “power” is the ORAC.
ORAC is the antioxidant capacity of foods; it is determined using the test, the Oxygen Radical Absorbance Capacity.

ORAC sets out all products of plant origin like fruits, vegetables, herbs and spices and vitamins such as vitamin A, C, E, quercetin and dihydroquercetin in terms of “power” antioxidants.

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Statins or dihydroquercetin – what’s better for lowering cholesterol

Increasingly difficult to persuade patients to change diet or physical activity. The reason for this condition is the rush that accompanies us every day. Doctors Cardiologists wonder whether in these circumstances does not recommend the use of prophylactic statin drugs in the fight against cholesterol (action is based on the block in the liver reductase enzyme hydroksymetyloglutarylo-CoA). In today’s post I will try to explain the similarities and differences of statin drugs and dihydroquercetin-the measure of the use of medical and preventive .In accordance with the recommendations of both the European and American treatment of lipid disorders main objective is the reduction of LDL-cholesterol with statin drugs. This is the standard therapy that reduces the level of cholesterol (and triglycerides) in the blood.

The scale of the problem can provide the quantity of drugs sold. Sales of the drug under the trade name Lipitor in 2006 stood at 12.9 billion dollars, making it the most popular prescription drug in the world. You have to just think about how many of these patients have side effects?

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Dihydroquercetin as a means of preventative

Very often I hear the statement that his grandfather, father, mother sister suffered from this or that. There’s a lot of truth. Through our genes we inherit all the baggage of our ancestors. Often we not even knowing that we are in the risk group.
Group risk does not mean, however, that we will be sick but that we are prone to this disorder. We can only help him to our way of life and conscious choice.
Make individual surveys on our health we can do at home, answering a few questions: who in the family was ill, or suffering from still if this is disorder classified as lifestyle diseases (list below), or died. Useful will also be talk with loved ones, and watch.
If the answer is affirmative then you are probably at group of risk.

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Heart attack-visible as a result of damage to the blood vessels

The reactive oxygen species are considered to be the factor pathogenetic heart dysfunction induced by ischemia and in the development of congestive arrest, what was confirmed in 2000. Ide and partners were making direct measurement of increased generation of radical system in inefficient heart.

It has been shown that to increased generation of free radicals occur during myocardial infarction and in the development of cardiomyopathy. Research of the last decade show that reactive oxygen species can induce arrhythmia and that increased production of reactive oxygen species occurs during cardio-surgical treatments. Free radical reactions seem also to play a key role in recoil after a heart transplant.

One of the key elements affecting the correct functioning of the heart beat are the capillaries (the capillary) which is supplied oxygen and nutrients to the cells.
Suction disorders the bloodstream as a result of failure of oxygen cell suffocated and starves, which leads to the disease and destroy cells. Professor Sylwester Terek, recommended that you provide the body with antioxidants trapping free radicals.

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Cells function of our body depends on a continuous supply of oxygen from the blood. If the blood supply to a tissue would cease, the situation becomes very serious. After a few or a several minutes of cut-off of oxygen supply (depending on the type of tissue) in the tissue are irreversible changes. Many studies of this type was performed on the heart muscle. They showed that few minute cutting off blood supply to the heart muscle causing arrhythmia, which persists spontaneously after a certain time. Longer, few or ten minutes ischemia results in an characteristic set of changes, known as the “stunned heart” or systolic heart disorders of abnormal contractions of the heart, which are not accompanied by myocardial necrosis. These changes will go away after a few-dozen days. Ischemia (part) of the heart muscle lasting longer than several minutes causes it to die off.


Heart arrhythmias can lead to serious and irreversible changes in the body. The use of Dihydroquercetin followed by improvement of microcirculation and contractility of the myocardium, coronary blood flow, and decrease the viscosity of the blood.

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Everything you should know about Taxifolin