Persons suffering from diabetes often accompanied problems with the skin and its diseases including thrush. The main reason for skin hypersensitivity in the person with diabetes are vascular lesions (diabetic angiopathia), which, in the same way may relate to the larger and smaller vessels. Simply put, we can say that the excess sugar in the blood leads to degenerative changes in capillaries, arterioles, and veins, resulting in impairment of vascular and malnutrition of the skin.
Diabetes affects yeast and fungal infection caused by fluctuations in blood sugar levels that facilitate the development of micro-organisms. Dihydroquercetin helps in the treatment of ringworm. In 2009 year, in the published work, its purpose was to investigate the impact of dihydroquercetin on intensity of LPO processes (deregulation of lipid peroxidation of lipids) and degree of endogenous intoxication in patients with diabetes during treatment for fungal nail infection by using the medicine Orungal.
Studies have been carried out before Davidova, T.V., Zoloeva, E.I., Blokhina N.N., the representatives of the Russian Scientific Centre of the Russian Academy of Sciences Oncology at the Russian State University of Medicine in Moscow. Participation in the study was attended by thirty-seven patients between the ages of 30 to 68 years for type 1 diabetes (9 patients) and type 2 (28 patients) with a fungal nails. All patients have experienced changes in the microcirculatory of the lower limbs and manifestations of peripheral polyneuropathy (peripheral nerve damage syndrome). The degree of fungal nail infection was evaluated by CIEDOS index (index: a clinical assessment of the degree of fungal nail infection by Sergeev). 20 patients in Group 1 were given the medicine Orungal 400 mg/day (the period of treatment determine CIEDOS) and 17 patients in group 2 were given both Orungal and dihydroquercetin at a dose of 120 mg/day for 12-16 weeks.
Blood analysis was conducted at the beginning and at the end of the test. The intensity of the LPO processes was evaluated through the contents of MDA (malondialdehyde is a product of the lipid peroxidation process which causes, among other things, reducing the hydrophobicity of the lipid interior of the membrane, depolarizes the membrane , disrupts the lipid membrane asymmetry, inhibits the activity of membrane enzymes inhibits activity of proteins involved in the transport) in the blood plasma as well as red blood cell enzymes activity “from the first line of antioxidant protection of superoxide dismutase (SOD) and catalase. At the start of the test, the initial level of MDA in all investigated patients averaged 50% more (the normal level of p < 0.05), indicating an abnormal free radicals processes. Increased LPO (deregulation of lipid peroxidation) can be the result of an increase in the activity of enzymes that catalyze the formation of peroxide and/or decreasing the activity of the enzymes which prevent the formation of peroxide. Increasing levels of MDA may also reflect abnormal enzymatic mechanisms of antioxidant defense
However, the evaluation of antioxidant protection enzymes showed an increase in activity of reactive oxygen species by 20%, while catalase activity was no different from the norm. In group 1 while taking Orungal observed decrease in MDA. Demonstrated that the levels of MDA and activity of reactive oxygen species and catalase did not differ from the initial values that indicates the lack of toxic action of medicine Orungal on the body. However, there has been a significant reduction in the level of MDA (from 6.29 to 0.24 ± 0.18 ± 5.31 mcmol/l) in group 2, which was administered the medicine Orungal and dihydroquercetin. However, the actions of reactive oxygen species and catalase in these patients are not different from background values. Scientists believe that dihydrokquercetin as a representative of flavonoids class, has lowered the concentration of MDA indirectly, through the effects of lipid peroxide and does not affect the activity of enzymes antioxidant protection. It was found that the LPO (deregulation of lipid peroxidation) plays an important role in the pathogenesis of various diseases. It is associated not only with an increase in the concentration of toxic oxidation products, but also with changes in lipid content. MDA may lead to modification of the physical properties of the cell membrane, changing its permeability.
In addition, it also affects the activity of many enzymes. Its activation in macrophages leads to initiate inflammatory process. In addition, aldehydes, which are formed when the LPO can cause cracks in the strands of DNA, are cytotoxic, acting mutagenic and carcinogenic. The researchers came to the conclusion that dihydrquercetin without affecting the activity of antioxidant enzymes, reduces the negative effects of the oxidation process ( free radical process), perhaps due to the destruction of oxidative low density lipoprotein. This is confirmed by data indicating the normalization of lipid spectrum in patients with diabetes who received dihydroquercetin and therefore show the hipolipidemic effect.
Application of dihydroquercetin decreased lipid radicals and increased formation of nitric oxide by platelets by inhibiting platelet activation. The data point to the desirability of the dihydroquercetin use as a supplement the comprehensive treatment of patients, who in the course of the disease are accompanied by an intensification of the free radical oxidation. In this connection, the dihydroquercetin can be used successfully as an anti-platet and anti-inflammatory preparation.
If you are interested in other ailments associated with diabetes, click following links:
1/ Free- Radical Oxidation in Patients with Diabetes Mellitus Supplemented with Diquertin, Davidova, T.V.1, Zoloeva, E.I., N.N. Blokhin Russian Oncological Scientific Center of Russian Academy of Science Russian State Medical University, Moscow, Russia, This work was presented in the International Scientific conference “Fundamental researches”, Croatia, July, 25 – August, 1 2009. The article was received by publication on 08.12.2009.
2/Influence of Diquertin on the intensiveness of lipid peroxidation process in patients with Diabetes during treatment of fungal nail infection Dzutseva, E.I., Kulagin, V.I., Burov, S.A., Davydova, T.V., Zubrihina, T .N. , Gorozhanskaya, E.G. Russian State Medical University, N.N. Bpohin Russian Cancer Research Center. Russian Academy of Medical Science Moscow
3/Mechanisms Underlying Diquertin-Mediated Regulation of Neutrophil Function in Patients with Non-Insulin-Dependent Diabetes Mellitus N. F. Fedosova, S. V. Alisievich, K. V. Lyadov, E. P. Romanova, I. A. Rud’ko, and A. A. Kubatiev Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 137, No. 2, pp. 164-167, February, 2004 Original article submitted September 17, 2003, Bulletin of Experimental Biology and Medicine, No. 2, 2004 GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGY
4/ Znaczenie zaburzeń układu prooksydacyjno -antyoksydacyjnego dla etiopatologii cukrzycy,dr n. med. Małgorzata Mrowicka Postępy Hig Med Dosw (online), 2011; 65: 534-541 Zakład Chemii i Biochemii Klinicznej, Uniwersytet Medyczny w Łodzi http://www.phmd.pl/abstracted.php?level=5&ICID=956085
5/Cukrzyca: Problemy ze skórą przy cukrzycy, Anna Jarosz, konsultacje dr n. med. Magdalena Ciupińska, dermatolog http://www.poradnikzdrowie.pl/zdrowie/cukrzyca/cukrzyca-problemy-ze-skora-przy-cukrzycy_35675.html